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Related Experiment Video

Updated: Jul 20, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

Gastrointestinal stromal tumor colliding with angiosarcoma.

Mala Adhikari1, Mark Li-cheng Wu, Xiaohui Zhao

  • 1Department of Pathology and Laboratory Medicine, University of California Irvine Medical Center, 101 The City Drive South Building 10, Room 104, Orange, CA 92868, USA.

International Journal of Surgical Pathology
|September 9, 2006
PubMed
Summary

This study reports the first known case of a gastric tumor collision between a gastrointestinal stromal tumor and angiosarcoma. This rare dual diagnosis highlights unique challenges in gastric cancer pathology and treatment.

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Collision tumors involving the stomach are exceptionally rare.
  • Gastrointestinal stromal tumors (GIST) and angiosarcomas are distinct malignant neoplasms.
  • No prior reports exist of a collision between GIST and angiosarcoma in the gastric setting.

Observation:

  • An 81-year-old male presented with dyspepsia and a large gastric mass.
  • Histopathological examination revealed a biphasic tumor.
  • The predominant component showed spindle cells positive for CD117 (c-kit), consistent with GIST.

Findings:

  • The tumor exhibited distinct areas of gastrointestinal stromal tumor (GIST) and angiosarcoma.
  • Angiosarcoma components displayed malignant spindle cells within vascular channels, positive for vascular markers and focally for CD117.

Related Experiment Videos

Last Updated: Jul 20, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
07:21

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor

Published on: May 2, 2022

  • The co-occurrence of GIST and angiosarcoma within a single gastric mass is unprecedented.

    • Implications:

    • This case expands the understanding of gastric tumor heterogeneity.
    • It underscores the importance of comprehensive histopathological evaluation for complex gastric masses.
    • Further research may be needed to elucidate the pathogenesis and optimal management strategies for such rare collision tumors.