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Mirtazapine for severe gastroparesis unresponsive to conventional prokinetic treatment
Sung-wan Kim1, Il-seon Shin, Jae-min Kim
1Department of Psychiatry, Chonnam National Univ. Hospital, 8 Hak-dong, Dong-ku, Kwangju 501-757, Republic of Korea.
Abstract:
Gastroparesis is a condition of abnormal gastric motility characterized by delayed gastric emptying without evidence of mechanical outlet obstruction. The authors describe complete remission of recurrent postprandial discomfort, nausea, and vomiting within 1 week of starting mirtazapine in a gastroparetic patient who had failed to respond, in 7 months, to conventional prokinetics (erythromycin, metoclopramide, domperidone, perphenazine, itopride, bethanechol, and/or tegaserod) and pyloric injection of botulinum toxin. This is the first report to show that mirtazapine may be an effective alternative when gastroparesis is refractory to conventional measures.
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