Related Experiment Video
Updated: Jul 20, 2026

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
Published on: May 2, 2017
Cardiovascular dysfunction in dogs associated with critical illnesses.
O Lynne Nelson1, Pam A Thompson
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-7060, USA.
Severe systemic illness in dogs can cause left ventricular dysfunction, often linked to sepsis or cancer. Despite this cardiac issue, congestive heart failure signs were absent, but outcomes were poor, with most dogs dying quickly.
Area of Science:
- Veterinary Cardiology
- Canine Internal Medicine
- Critical Care
Background:
- Left ventricular dysfunction (LVD) can occur in dogs with severe systemic illness.
- Common causes of severe systemic illness in dogs include sepsis and cancer.
- The presentation and outcomes of LVD in critically ill dogs require further elucidation.
Purpose of the Study:
- To investigate the prevalence and clinical characteristics of left ventricular dysfunction in dogs with severe systemic illness.
- To determine the association between LVD and specific diagnoses in critically ill dogs.
- To evaluate the short-term prognosis for dogs with LVD and severe systemic illness.
Main Methods:
- Retrospective review of medical records from 16 dogs diagnosed with left ventricular dysfunction.
- Analysis of clinical signs, diagnostic findings, and outcomes.
- Correlation of LVD with underlying systemic diseases such as sepsis and cancer.
Main Results:
- The most frequent diagnoses associated with LVD were sepsis (n=?) and cancer (n=?).
- No dogs presented with clinical signs of congestive heart failure, despite documented LVD.
- Generalized weakness was a common presenting complaint (15/16 dogs).
- A high mortality rate was observed, with 75% (12/16) of dogs dying or being euthanized within 15 days.
- The average survival time was short, at 3.6 days post-admission.
Conclusions:
- Left ventricular dysfunction is a significant complication in dogs with severe systemic illness, particularly sepsis and cancer.
- The absence of congestive heart failure signs does not preclude a poor prognosis in these cases.
- Rapid mortality underscores the critical nature of LVD in the context of severe systemic disease in dogs.
Related Concept Videos
Cardiomyopathy II: Dilated Cardiomyopathy
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Cardiomyopathy VI: Nursing Management
Heart Failure III: Clinical Manifestations
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure

