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Microstructural development of human brain assessed in utero by diffusion tensor imaging.
Tony Bui1, Jean-Luc Daire, François Chalard
1Department of Paediatric Imaging, Hôpital Robert Debré, AP-HP, 48 boulevard Serurier, Paris 75019, France.
Pediatric Radiology
|September 9, 2006
Summary
Diffusion tensor imaging reveals fetal white matter maturation in utero. This technique quantitatively assesses microstructural changes, aiding understanding of brain development before birth.
Area of Science:
- Neuroimaging
- Developmental Neuroscience
- Medical Physics
Background:
- Diffusion-weighted MR imaging (DWI) is crucial for assessing infant white matter development.
- Comparing fetal and preterm infant cerebral diffusion properties can reveal the effects of premature birth on brain maturation.
Purpose of the Study:
- To evaluate in utero maturation-dependent microstructural changes in fetal cerebral white matter.
- Utilizing diffusion tensor MR imaging for quantitative assessment.
Main Methods:
- Diffusion tensor MR imaging (b=700 s/mm(2)) was performed on 24 fetuses (31-37 weeks gestation).
- Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in specific white matter regions.
Main Results:
- Significant differences in ADC were observed across centrum semiovale, corpus callosum, and pyramidal tract.
- Age-related decreases in ADC and increases in FA were noted in the pyramidal tract and corpus callosum towards term.
Conclusions:
- In utero diffusion tensor imaging offers quantitative insights into fetal white matter microstructural development.
- Advancements in diffusion tensor imaging are expected to enhance anisotropic parameter assessment.
