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Effects of thiazolidinediones on stroke recovery: a case-matched controlled study
1Department of Rehabilitation Medicine, and Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, University Hospital, Konkuk University, Seoul, South Korea.
Background And Purpose:
Anti-inflammatory therapy decreases infarct size and enhances stroke recovery. Thiazolidinedione peroxisome proliferator-activated receptor (PPAR)gamma agonists have potent anti-inflammatory and insulin-sensitizing anti-diabetic actions.
Methods:
Thirty stroke patients with type 2 diabetes admitted for acute inpatient stroke rehabilitation receiving pioglitazone or rosiglitazone were matched for age, sex, initial FIM(TM) score and interval post-stroke with 30 stroke patients with type 2 diabetes not receiving thiazolidinediones. Relevant outcome variables were compared for both groups.
Results:
The thiazolidinedione treated group showed significantly greater mean improvement in FIM(TM) score compared to control group (25.6 +/- 10.2 SD vs. 19.8 +/- 10.5, respectively, P = 0.015). There was no significant difference in length of rehabilitation hospital stay (24.2 +/- 7.6 vs. 25.1 +/- 7.4 days, P = 0.657) or final discharge destination (home/institution, 19/11 versus 17/13, P = 0.792).
Conclusions:
Use of thiazolidinediones was associated with enhanced functional recovery in stroke patients with type 2 diabetes.