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Updated: Jul 20, 2026
A Modified Vessel-Sparing Microsurgical Vasoepididymostomy
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Malacoplakia and spermatic granuloma complicating vasectomy
Margrét Agnarsdóttir1, Birgitta Carlén, Roger Willén
1Pathology and Cytology, Centre for Laboratory Medicine, Uppsala University Hospital, S-75185 Uppsala, Sweden.
Abstract:
Malacoplakia is a granulomatous disease with a histiocytic infiltrate containing calcified structures called Michaelis-Gutmann bodies. These structures are considered to represent an abnormal response to infection involving defective lysosomes and abnormal microbubular assembly. The disease most frequently involves urinary and genital tracts, but has also been described from most other organs. Here we present the first case of malacoplakia only involving the vas deferens.
Insights
Malacoplakia, a rare granulomatous disease, typically affects the urinary and genital tracts. This study reports the first documented case exclusively involving the vas deferens, expanding the known organ manifestations of this condition.
Area of Science:
- Pathology
- Histopathology
- Infectious Disease
Background:
- Malacoplakia is a rare granulomatous inflammatory condition characterized by the presence of Michaelis-Gutmann bodies.
- Pathogenesis is linked to defective lysosomal function and abnormal microtubular assembly in response to infection.
- While commonly affecting the urinary and genital tracts, it can occur in various organs.
Observation:
- This report details a unique case of malacoplakia.
- The observed case presented with exclusive involvement of the vas deferens.
Findings:
- The study identifies the vas deferens as a potential site for malacoplakia.
- This represents the first reported instance of malacoplakia localized solely to the vas deferens.
Implications:
- This finding broadens the differential diagnosis for vas deferens pathologies.
- It suggests a need to consider malacoplakia in cases of unexplained vas deferens inflammation.
- Further research may elucidate specific risk factors or mechanisms for isolated vas deferens malacoplakia.
