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Updated: Jul 20, 2026
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Expression of CD40 and CD40L on peripheral blood mononuclear cells in patients with condyloma acuminatum
Dongxian Liu1, Wen Jiang, Xingping Chen
1Department of Dermatology, Tongji Hospital Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Abstract:
To observe the expression of CD40/CD40L on peripheral blood mononuclear cells (PBMC) in patients with condyloma acuminatum (CA), flow cytometry was employed to examine the expression of CD40 and CD40L on PMBC in 36 patients with CA and 20 healthy controls. Our results showed that mean level of CD40 expression in CA patients was significantly lower than that in the controls (6.58% +/- 2.74% vs 14.81% +/- 6.12%, t = 5.703, P < 0.05); the average level of CD40L in CA patients was also significantly lower than that in the controls (0.73% +/- 0.54% vs 2.67% +/- 2.43%, t = 3.532, P < 0.05). Our results suggest that the reduced costimulatory interaction of CD40 and CD40L in CA patients may be one of the important factors responsible for the low cellular immunity.
