Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generalized linear porokeratosis.

Emine Dervis1, Cuyan Demirkesen

  • 1Dermatology Department, Haseki General Hospital, Istanbul University Cerrahpasa Medical School, Istanbul, Turkey. eminedervis@hotmail.com

International Journal of Dermatology
|September 12, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Annular Eruption in 12-Year-Old Boy.

Pediatric dermatology·2026
Same author

Foreign body granuloma following leech therapy in hidradenitis suppurativa: A case complicated by lymphedema.

Dermatology online journal·2026
Same author

Genomic Profiling of Intraocular Leiomyomas Reveals Recurrent Copy Number Alterations.

Translational vision science & technology·2025
Same author

Cutaneous B-cell pseudolymphoma treated with imiquimod.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2025
Same author

A case of vulvar lichen planus pigmentosus with true melanocytic nests mimicking a melanocytic lesion.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2025
Same author

Prurigo Pigmentosa: Review of the Literature, Impact of Ketogenic Diets and Proposal of a Hypothesis.

Indian journal of dermatology·2025

This case study highlights linear porokeratosis, a rare skin condition. Topical tretinoin effectively treated widespread hyperkeratotic lesions, showing significant improvement and long-term stability.

Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Linear porokeratosis is a rare genodermatosis characterized by lesions following Blaschko's lines.
  • It typically presents in childhood with hyperkeratotic papules and plaques.

Observation:

  • A 23-year-old woman presented with widespread, lifelong skin lesions following Blaschko's lines.
  • Lesions included hyperkeratotic plaques with central atrophy and raised borders, nail dystrophy, and lichenoid papules.
  • Histopathology confirmed epidermal invagination with a cornoid lamella, consistent with porokeratosis.

Findings:

  • Topical tretinoin 0.05% demonstrated marked improvement in hyperkeratosis within 4 weeks.
  • Lesions almost disappeared after 10 weeks of treatment.
  • The patient maintained stability with twice-weekly application for one year.

Related Experiment Videos

Implications:

  • Topical tretinoin is a viable and effective treatment for linear porokeratosis.
  • Early and consistent treatment can lead to significant cosmetic improvement and long-term disease control.
  • This case underscores the importance of recognizing and managing rare dermatological conditions.