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Related Experiment Videos

Platelet hyperreactivity generalizes to multiple forms of stimulation.

D L Yee1, A L Bergeron, C W Sun

  • 1Department of Pediatrics, Hematology-Oncology Section, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Journal of Thrombosis and Haemostasis : JTH
|September 12, 2006
PubMed
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Platelet hyperreactivity, a cardiovascular risk factor, is consistently identified by epinephrine aggregometry. This global hyperfunction affects adhesion, activation, and aggregation, and is linked to GNB3 gene variants.

Area of Science:

  • Cardiovascular Research
  • Hematology
  • Platelet Biology

Background:

  • Platelet hyperreactivity is a significant cardiovascular risk factor.
  • Standardized methods for measuring platelet hyperreactivity are lacking.
  • Epinephrine aggregometry at submaximal concentrations identifies reproducible in vitro platelet hyperreactivity.

Purpose of the Study:

  • To investigate the relationship between epinephrine-induced platelet reactivity and other platelet functional assays in healthy individuals.
  • To characterize the platelet phenotype associated with epinephrine hyperreactivity.

Main Methods:

  • Studied 386 healthy individuals.
  • Assessed platelet adhesion, activation, aggregation to various agonists, and response to shear stress.

Related Experiment Videos

  • Analyzed candidate genes, including GNB3, for associations with epinephrine hyperreactivity.

    • Main Results:

    • Individuals with epinephrine hyperreactivity showed hyperfunction in adhesion, activation, and aggregation to multiple agonists.
    • This global hyperfunction extended to responses to shear stress.
    • A polymorphism in the GNB3 gene was associated with epinephrine hyperreactivity (P = 0.03).

    Conclusions:

    • Robust epinephrine aggregation defines a global platelet hyperreactive phenotype, useful for identifying individuals at risk for arterial thrombosis.
    • Common signaling pathways, potentially involving G protein subunits, may underlie various forms of platelet hyperreactivity.