Related Experiment Video

Updated: Jul 20, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Characterisation of Neisseria meningitidis C:2b:P1.2,5 isolates in Poland

A Skoczyńska1, M Kadłubowski, I Waśko

  • 1Department of Epidemiology and Clinical Microbiology, National Reference Centre for Bacterial Meningitis, National Institute of Public Health, Warsaw, Poland. skoczek@cls.edu.pl

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|September 12, 2006
PubMed

Insights

This study characterized Neisseria meningitidis C:2b:P1.2,5 in Poland. While this invasive strain is linked to penicillin resistance elsewhere, Polish isolates showed limited susceptibility issues.

Area of Science:

  • Microbiology
  • Epidemiology
  • Immunology

Background:

  • Neisseria meningitidis serogroup C is a significant cause of bacterial meningitis.
  • The C:2b:P1.2,5 strain has emerged as predominant in Poland.
  • This clone's global emergence has prompted public health interventions.

Purpose of the Study:

  • To characterize the predominant Neisseria meningitidis C:2b:P1.2,5 isolates in Poland.
  • To assess the genetic relatedness and antimicrobial susceptibility of these isolates.
  • To understand the epidemiological significance of this emerging clone.

Main Methods:

  • Whole-cell ELISA and pulsed-field gel electrophoresis (PFGE) for isolate typing.
  • Multilocus sequence typing (MLST) for genotypic analysis of invasive isolates.
  • Assessment of penicillin susceptibility.

Main Results:

  • 44 Neisseria meningitidis isolates (25 invasive, 19 contact carriers) were analyzed.
  • All invasive isolates belonged to the ST-8 complex/cluster A4.
  • Only one isolate exhibited decreased susceptibility to penicillin.

Conclusions:

  • The predominant Neisseria meningitidis C:2b:P1.2,5 clone in Poland is genetically uniform (ST-8 complex/cluster A4).
  • Unlike in other regions, this clone currently shows low levels of penicillin non-susceptibility in Poland.
  • Continued surveillance is crucial to monitor potential changes in antimicrobial resistance patterns.

More Related Videos

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae09:12

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/4306:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

Related Concept Videos

Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...