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Published on: January 22, 2018
Cognitive-behavioural stress management does not improve biological cardiovascular risk indicators in women with
M Claesson1, L S Birgander, J-H Jansson
1Department of Public Health and Clinical Medicine/Medicine, Umeå University Hospital, Umeå, Sweden. maria.claesson@medicin.umu.se
Insights
A cognitive-behavioural intervention improved psychosocial well-being in women with ischaemic heart disease (IHD), but did not significantly alter key biochemical cardiovascular risk indicators. This suggests psychological well-being may not directly impact biological markers of heart disease risk.
Area of Science:
- Cardiology
- Psychosomatic Medicine
- Behavioral Science
Background:
- Psychosocial factors like stress and vital exhaustion are linked to increased cardiovascular event risk.
- Women experience greater psychosocial distress post-myocardial infarction compared to men.
- Previous research indicated a cognitive-behavioural intervention improved psychosocial well-being in women with ischaemic heart disease (IHD).
Purpose of the Study:
- To investigate if improved psychosocial well-being from a cognitive-behavioural intervention is associated with better biochemical cardiovascular risk indicators in women with IHD.
- To test the hypothesis linking psychological improvements to biological markers of cardiovascular health.
Main Methods:
- A randomized-controlled trial was conducted in northern Sweden involving women with IHD.
- Participants were assigned to a 1-year cognitive-behavioural stress management program or usual care.
- Outcomes included various biochemical markers (e.g., hs-CRP, fibrinogen, leptin) and psychosocial variables.
Main Results:
- No significant differences were observed between the intervention and control groups in biochemical risk indicators such as waist circumference, hs-CRP, fibrinogen, or HOMA2-IR.
- Changes in psychosocial variables were not statistically associated with changes in any measured biological cardiovascular risk indicators.
- The cognitive-behavioural stress management program did not lead to improvements in intermediate biochemical targets related to metabolic syndrome and IHD.
Conclusions:
- While the cognitive-behavioural stress management program positively affected psychosocial outcomes like stress and vital exhaustion, it did not improve intermediate biochemical cardiovascular risk markers.
- The findings challenge a direct cause-effect relationship between psychological well-being and biological cardiovascular risk indicators.
- The study suggests that interventions targeting psychological well-being may not translate into measurable improvements in specific biological markers of cardiovascular risk.
Objectives:
Psychosocial factors, such as stress and vital exhaustion, are associated with an increased risk of cardiovascular events, and women report more psychosocial ill-being after an acute myocardial infarction than men. We have earlier shown that a cognitive-behavioural intervention in women with ischaemic heart disease (IHD) improved psychosocial well-being. In the present study, we tested the hypothesis that the improvement in psychosocial well-being is associated with an improvement in biochemical indicators of cardiovascular risk.
Design:
Randomized-controlled trial in northern Sweden.
Setting:
Outpatient care.
Subjects:
Women with IHD were randomized to either a 1-year cognitive-behavioural stress management programme or usual care. Of the 159 women who completed the study, 77 were in the intervention group, and 82 in the control group.
Interventions:
A 1-year cognitive-behavioural stress management programme versus conventional care.
Results:
Group assignment was not found to be a determinant of waist circumference, high sensitive C-reactive protein (hs-CRP), fibrinogen, von Willebrand factor (vWF), plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) activity, tPA antigen, tPA-PAI-1 complex, leptin, or HOMA2 insulin resistance index (HOMA2-IR) at follow up. Changes in psychosocial variables were not associated with changes in any of the biological risk indicators.
Conclusions:
Even if our cognitive-behavioural stress management programme had effects on proximal targets, such as stress behaviour and vital exhaustion, we found no improvement in intermediate biochemical targets related to the metabolic syndrome and IHD. Our results challenge the proposition that the relationship between psychological well-being and biological cardiovascular risk indicators is a direct cause-effect phenomenon.
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