Cognitive-behavioural stress management does not improve biological cardiovascular risk indicators in women with

M Claesson1, L S Birgander, J-H Jansson

  • 1Department of Public Health and Clinical Medicine/Medicine, Umeå University Hospital, Umeå, Sweden. maria.claesson@medicin.umu.se

Journal of Internal Medicine
|September 12, 2006
PubMed

Insights

A cognitive-behavioural intervention improved psychosocial well-being in women with ischaemic heart disease (IHD), but did not significantly alter key biochemical cardiovascular risk indicators. This suggests psychological well-being may not directly impact biological markers of heart disease risk.

Area of Science:

  • Cardiology
  • Psychosomatic Medicine
  • Behavioral Science

Background:

  • Psychosocial factors like stress and vital exhaustion are linked to increased cardiovascular event risk.
  • Women experience greater psychosocial distress post-myocardial infarction compared to men.
  • Previous research indicated a cognitive-behavioural intervention improved psychosocial well-being in women with ischaemic heart disease (IHD).

Purpose of the Study:

  • To investigate if improved psychosocial well-being from a cognitive-behavioural intervention is associated with better biochemical cardiovascular risk indicators in women with IHD.
  • To test the hypothesis linking psychological improvements to biological markers of cardiovascular health.

Main Methods:

  • A randomized-controlled trial was conducted in northern Sweden involving women with IHD.
  • Participants were assigned to a 1-year cognitive-behavioural stress management program or usual care.
  • Outcomes included various biochemical markers (e.g., hs-CRP, fibrinogen, leptin) and psychosocial variables.

Main Results:

  • No significant differences were observed between the intervention and control groups in biochemical risk indicators such as waist circumference, hs-CRP, fibrinogen, or HOMA2-IR.
  • Changes in psychosocial variables were not statistically associated with changes in any measured biological cardiovascular risk indicators.
  • The cognitive-behavioural stress management program did not lead to improvements in intermediate biochemical targets related to metabolic syndrome and IHD.

Conclusions:

  • While the cognitive-behavioural stress management program positively affected psychosocial outcomes like stress and vital exhaustion, it did not improve intermediate biochemical cardiovascular risk markers.
  • The findings challenge a direct cause-effect relationship between psychological well-being and biological cardiovascular risk indicators.
  • The study suggests that interventions targeting psychological well-being may not translate into measurable improvements in specific biological markers of cardiovascular risk.
Abstract

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