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Epidermal sphingolipids: metabolism, function, and roles in skin disorders

Walter M Holleran1, Yutaka Takagi, Yoshikazu Uchida

  • 1Department of Dermatology, School of Medicine, University of California San Francisco, 94121, USA. walt.holleran@ucsf.edu

FEBS Letters
|September 12, 2006
PubMed
Summary

The epidermis regulates ceramide levels through lipid precursor hydrolysis, preventing harmful accumulation. Altered sphingolipid metabolism is linked to skin disease severity.

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