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Related Experiment Video

Updated: Jul 20, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Stress cardiovascular/autonomic interactions in mice.

Vera M A Farah¹, Luis F Joaquim, Mariana Morris

¹Boonshoft School of Medicine, Wright State University, Department of Pharmacology and Toxicology, Dayton, OH 45401, United States.

Physiology & Behavior

|September 12, 2006

Summary

This study reveals the autonomic nervous system

Area of Science:

Cardiovascular Physiology
Autonomic Nervous System Research
Stress Response Mechanisms

Background:

The autonomic nervous system (ANS) regulates cardiovascular function during stress.
Understanding the specific roles of sympathetic and parasympathetic branches is crucial for stress response research.

Purpose of the Study:

To investigate the role of the autonomic nervous system in cardiovascular responses to acute stress in mice.
To elucidate the specific contributions of cholinergic, beta1-adrenergic, and alpha1-adrenergic pathways to stress-induced cardiovascular changes.

Main Methods:

Utilized radiotelemetric blood pressure (BP) monitoring in conscious C57/BL6 mice.
Employed autoregressive spectral analysis to analyze pulse interval (PI) and systolic arterial pressure (SAP) variability.

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Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

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Last Updated: Jul 20, 2026

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Cardiac Stress Test Induced by Dobutamine and Monitored by Cardiac Catheterization in Mice

Published on: February 10, 2013

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice

Published on: February 14, 2021

Administered cholinergic (atropine), beta1-adrenergic (atenolol), and alpha1-adrenergic (prazosin) antagonists to assess autonomic blockade effects during stress.

Main Results:

Acute stress significantly increased BP, heart rate (HR), and both PI and SAP variability.
Cholinergic blockade (atropine) reduced tachycardia and abolished increases in PI variability and its low-frequency component.
Beta1-adrenergic blockade (atenolol) attenuated stress-induced increases in PI and SAP variability.
Alpha1-adrenergic blockade (prazosin) reduced stress-induced tachycardia and blunted increases in PI (LF component) and SAP variability.

Conclusions:

The cholinergic system is fundamental for maintaining heart rate variability in mice.
Sympathetic and parasympathetic pathways differentially mediate cardiovascular and variability changes during stress.
Radiotelemetry coupled with pharmacological antagonism provides a precise method for dissecting autonomic roles in stress responses.