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Basic transplantation immunology.

Douglas A Hale¹

¹Transplantation Branch, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Douglas.Hale@jax.ufl.edu

The Surgical Clinics of North America

|September 12, 2006

Summary

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The immune system protects us but attacks beneficial transplanted organs. Understanding this alloimmune response is key to developing better immunosuppression for organ transplant patients.

Area of Science:

Immunology
Transplantation Medicine

Background:

The human immune system provides layered protection against pathogens.
Historically, immune surveillance for foreign cells was considered advantageous.
Solid organ transplantation presents a challenge as the immune system attacks beneficial foreign tissue.

Purpose of the Study:

To understand the factors initiating and perpetuating the alloimmune response.
To improve immunosuppressive strategies for organ transplant recipients.

Main Methods:

This abstract does not specify methods.

Main Results:

This abstract does not specify results.

Conclusions:

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Further understanding of the alloimmune response is crucial.
This knowledge will lead to more refined and tolerable immunosuppressive strategies for organ transplantation.