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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Related Experiment Video

Updated: Jul 20, 2026

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment
07:01

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

Working memory training decreases hippocampal neurogenesis.

P Mohapel1, K Mundt-Petersen, P Brundin

  • 1Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, BMC A10, 221 84 Lund, Sweden.

Neuroscience
|September 12, 2006
PubMed
Summary

Prolonged spatial working memory training in rats reduced hippocampal neurogenesis, possibly due to increased stress. Short-term training did not affect this process.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Background:

  • Adult hippocampal neurogenesis is linked to cognition, but its regulation by learning is complex.
  • Early studies suggested a straightforward relationship, but recent findings indicate a more nuanced interaction.

Purpose of the Study:

  • To investigate how the duration and task demands of spatial memory training impact adult hippocampal neurogenesis.
  • To determine if prolonged working memory training affects neurogenesis differently than reference memory training or shorter durations.

Main Methods:

  • Adult male rats were trained in the Morris water maze using either reference memory (4 days) or working memory (4 or 14 days) paradigms.
  • Neurogenesis was assessed by counting newborn hippocampal neurons.
  • Circulating corticosterone levels were measured to assess stress responses.

Main Results:

  • Four days of spatial training (reference or working memory) did not alter hippocampal neurogenesis.
  • Two weeks of working memory training significantly reduced the number of newborn hippocampal neurons compared to controls.
  • Maze training, especially working memory tasks, elevated corticosterone levels, suggesting increased stress.

Conclusions:

  • Prolonged spatial working memory training reduces adult hippocampal neurogenesis in rats.
  • This reduction may be partly mediated by stress-induced elevations in corticosterone.
  • The duration and type of spatial memory task are critical factors influencing hippocampal neurogenesis.