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Evolutionary systems biology: links between gene evolution and function.

Eugene V Koonin1, Yuri I Wolf

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. koonin@ncbi.nlm.nih.gov

Current Opinion in Biotechnology
|September 12, 2006
PubMed
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Evolutionary systems biology reveals links between gene function and evolution. Translational robustness may be a key factor driving protein evolution, offering fundamental biological insights.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Systems Biology

Background:

  • Genome-wide data accumulation has spurred the field of evolutionary systems biology.
  • Correlations exist between gene function (expression, network connectivity) and evolutionary traits (sequence evolution, gene loss).

Purpose of the Study:

  • To investigate whether gene functional variables influence gene evolution synergistically or are dominated by a single factor.
  • To explore the role of translational robustness in protein evolution.

Main Methods:

  • Multidimensional analysis of genomic data.
  • Examination of gene expression, knockout effects, and network properties.
  • Analysis of sequence evolution rates and gene loss propensity.

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Main Results:

  • Composite variables describing gene 'status' in genomic communities have been identified.
  • The number of translation events, linked to translational robustness, is a candidate for a major determinant of protein evolution.

Conclusions:

  • Evolutionary systems biology is yielding fundamental biological insights despite methodological immaturity.
  • Translational robustness presents a significant factor influencing protein evolution.