Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Inherited thrombophilias.

Michiel Coppens¹, Stef P Kaandorp, Saskia Middeldorp

¹Academic Medical Center, F4-276, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Obstetrics and Gynecology Clinics of North America

|September 12, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Venous Thromboembolism in Women on Estrogen Therapy: Presentation, Management, and Outcomes in the RIETE registry.

Blood advances·2026

Same author

Cross-Reactivity of Antiphospholipid Antibodies with Gut Commensal Proteins in Antiphospholipid Syndrome.

TH open : companion journal to thrombosis and haemostasis·2026

Same author

Heparin to prevent recurrent placenta-mediated pregnancy complications in women with antiphospholipid syndrome: a systematic review.

Research and practice in thrombosis and haemostasis·2026

Same author

Fatal Pulmonary Embolism in Professional Athletes: A Window Into a Broader VTE Problem.

Journal of the American College of Cardiology·2026

Same author

Predictors of Hematoma Expansion and Response to Andexanet in Patients With Intracerebral Hemorrhage: Secondary Analyses of the ANNEXA-I Randomized Clinical Trial.

Stroke·2026

Same author

Global survey of women's awareness of pregnancy- and postpartum-associated venous thromboembolism (World Thrombosis Day 2025).

Research and practice in thrombosis and haemostasis·2026

Same journal

Bridging Science and Practice in Gender-Affirming Care: A Compendium for Gynecologists.

Obstetrics and gynecology clinics of North America·2026

Same journal

Evidence, Clinical Expertise, and Research Gaps in Gender-Affirming Care.

Obstetrics and gynecology clinics of North America·2026

Same journal

Evaluation and Management of the Pediatric Gender-Diverse Patient.

Obstetrics and gynecology clinics of North America·2026

Same journal

Expanding Access to Cervical Cancer Screening for Transgender and Nonbinary Individuals.

Obstetrics and gynecology clinics of North America·2026

Same journal

Updates on Breast Cancer Screening and Special Considerations for Transgender Men and Women.

Obstetrics and gynecology clinics of North America·2026

Same journal

Contraceptive Needs of the Transmasculine Patient.

Obstetrics and gynecology clinics of North America·2026

See all related articles

Inherited thrombophilia increases risks for women's health issues like VTE. Clinical guidance is uncertain for pregnancy complications, necessitating further research.

Area of Science:

Hematology
Obstetrics & Gynecology
Genetics

Background:

Significant advancements in understanding inherited thrombophilias and their pathophysiology have occurred.
Observational studies link inherited thrombophilia to various women's health issues, notably venous thromboembolism (VTE).

Purpose of the Study:

To evaluate the clinical implications of inherited thrombophilia in women's health.
To address the uncertainty surrounding the management of women with inherited thrombophilia, particularly concerning pregnancy complications.

Main Methods:

Review of observational evidence linking inherited thrombophilia to women's health outcomes.
Analysis of existing epidemiologic data for VTE prevention counseling.

Main Results:

Related Experiment Videos

Epidemiologic evidence supports counseling for VTE prevention in women with inherited thrombophilia.
Clinical practice implications remain uncertain for women experiencing pregnancy complications like recurrent pregnancy loss and pre-eclampsia.

Conclusions:

While VTE risk is established, the role of inherited thrombophilia in other pregnancy complications requires further investigation.
Well-designed, placebo-controlled trials are essential to determine the harm-benefit ratio of interventions for women with inherited thrombophilia and pregnancy complications.