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Related Experiment Videos

Extremely elevated C-reactive protein.

Steven Vanderschueren1, Dries Deeren, Daniël C Knockaert

  • 1Department of General Internal Medicine, University Hospital, Leuven, Herestraat 49, B-3000 Leuven, Belgium.

European Journal of Internal Medicine
|September 12, 2006
PubMed
Summary

Extremely high C-reactive protein (CRP) levels, often above 500 mg/l, are typically caused by bacterial infections. This study found a high mortality rate, especially in cancer patients with elevated CRP.

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Area of Science:

  • Clinical Medicine
  • Biochemistry
  • Infectious Diseases

Background:

  • C-reactive protein (CRP) is a common inflammatory marker.
  • The clinical implications of very high CRP levels are not well understood.

Purpose of the Study:

  • To investigate the clinical significance and outcomes associated with extremely elevated C-reactive protein (CRP) levels.

Main Methods:

  • Retrospective analysis of electronic health records for patients with CRP > 500 mg/l in 2004.
  • Focused on patient demographics, diagnoses, microbiology, and mortality.

Main Results:

  • 130 patients had CRP > 500 mg/l (median age 62).
  • Infections, primarily bacterial (88%), were the main cause.

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  • Overall mortality was 36%, rising to 61% in patients with active malignancies.

    • Conclusions:

    • Extreme CRP elevation is predominantly linked to identifiable infections, particularly bacterial.
    • High mortality rates are associated with very high CRP levels, especially in cancer patients.