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[Damaging effect of 2 simian viruses on mammalian cell chromosomes]

A N Mustafina, M A Sabun, V P Grachev

    Voprosy Virusologii
    |May 1, 1975
    PubMed

    Insights

    Simian virus 5 (SV5) and Adenovirus SV15 cause genetic damage, including chromosome breaks, in various animal and human cells. This mutagenic effect can occur even if the viruses do not fully replicate within the host cells.

    Area of Science:

    • Virology
    • Genetics
    • Cell Biology

    Context:

    • Investigating the genotoxic potential of viral infections.
    • Understanding the mechanisms of viral-induced DNA damage.

    Purpose:

    • To determine if simian virus 5 (SV5) and Adenovirus SV15 exhibit mutagenic properties.
    • To assess viral mutagenicity across different cell types and replication states.

    Summary:

    • Simian virus 5 (SV5) induces chromosome breaks in human, cotton rat, hamster, and lamb kidney cells.
    • Adenovirus SV15 demonstrates mutagenic activity in human and cotton rat fibroblasts, and lamb kidney cell lines.
    • Viral mutagenicity was observed even without complete viral replication.

    Impact:

    • Highlights the potential for certain viruses to cause genetic instability.
    • Informs understanding of viral pathogenesis and oncogenesis.
    • Suggests non-replicative viral particles may still pose genotoxic risks.

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