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Updated: Jul 20, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
The Pregnancy in Polycystic Ovary Syndrome study: baseline characteristics of the randomized cohort including racial
Richard S Legro1, Evan R Myers, Huiman X Barnhart
1Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania 17033, USA. RSL1@PSU.EDU
Objective:
To report the baseline characteristics and racial differences in the polycystic ovary syndrome (PCOS) phenotype from a large multicenter clinical trial (PPCOS).
Design:
Double-blind, randomized trial of three treatment regimens (with extended release metformin or clomiphene citrate).
Setting:
Academic medical centers.
Patient(S):
Six hundred twenty-six infertile women with PCOS, aged 18-39 years, with elevated T levels and oligomenorrhea (exclusion of secondary causes), seeking pregnancy, with > or = 1 patent fallopian tube, normal uterine cavity, and a partner with sperm concentration > or = 20 x 10(6)/mL in > or = 1 ejaculate.
Intervention(S):
Baseline characterization.
Main Outcome Measure(S):
Historical, biometric, and biochemical measures of PCOS.
Result(S):
There were no significant differences in baseline variables between treatment groups. The overall mean (+/-SD) age of the subjects was 28.1 +/- 4.0 years, and the mean body mass index was 35.2 kg/m2 (+/-8.7). Polycystic ovaries (PCOs) were present in 90.3% of the subjects, and the mean volume of each ovary was 10 cm3 or more. Of the subjects, 7% had ovaries that were discordant for PCO morphology. At baseline, 18.3% of the subjects had an abnormal fasting glucose level (> 100 mg/dL). Asians tended to have a milder phenotype, and whites and African Americans were similar in these measures.
Conclusion(S):
The treatment groups were well matched for baseline parameters, and we have added further information to the PCOS phenotype.
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