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Measuring mechanical function in the failing heart.

Elliot McVeigh1

  • 1Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD 20892-1061, USA. emcveigh@nih.gov

Journal of Electrocardiology
|September 12, 2006
PubMed
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Magnetic resonance (MR) imaging techniques quantify mechanical changes in heart failure, aiding diagnosis and predicting treatment response in hypertrophic and dilated cardiomyopathy.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Heart failure involves detrimental changes in cardiac contraction and filling mechanics.
  • Familial hypertrophic cardiomyopathy presents with left ventricular hypertrophy, myofiber disarray, and diastolic dysfunction.
  • Dilated cardiomyopathy is associated with asynchronous left ventricular activation, often due to left bundle branch block.

Purpose of the Study:

  • To investigate the utility of advanced magnetic resonance (MR) imaging techniques for quantifying mechanical abnormalities in heart failure.
  • To assess the role of MR imaging in characterizing diastolic dysfunction in familial hypertrophic cardiomyopathy.
  • To evaluate the application of MR imaging in quantifying asynchronous activation in dilated cardiomyopathy and predicting response to resynchronization therapy.

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Main Methods:

  • Utilized magnetic resonance (MR) tissue tagging, MR cine phase contrast, and MR cine displacement encoding.
  • Applied these MR imaging methods to quantify regional myocardial shortening and relaxation.
  • Characterized late-activated regions in failing hearts for protein expression analysis.

Main Results:

  • MR imaging methods successfully quantified restrictive filling in familial hypertrophic cardiomyopathy.
  • Quantified asynchronous activation in dilated cardiomyopathy, correlating with pacing therapy response.
  • Enabled measurement of protein expression changes in late-activated myocardial regions.

Conclusions:

  • Advanced MR imaging techniques are valuable tools for assessing cardiac mechanics in heart failure.
  • These methods aid in understanding disease mechanisms and guiding therapeutic strategies.
  • MR imaging can predict response to resynchronization therapy in dilated cardiomyopathy.