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Published on: February 8, 2022
Electrocardiographic findings in patients with cryptogenic ischemic stroke and patent foramen ovale
Robert Belvís1, Rubén Gabriel Leta, Alejandro Martínez-Domeño
1Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. 32353rbn@comb.es
Insights
Electrocardiogram (ECG) crochetage is not a reliable indicator for identifying patent foramen ovale (PFO) in patients with cryptogenic stroke. Further research is needed to find characteristic ECG patterns for PFO detection.
Area of Science:
- Cardiology
- Neurology
Background:
- Electrocardiogram (ECG) crochetage is a pattern associated with atrial septal defects.
- Its prevalence in patients with patent foramen ovale (PFO) remains debated.
Purpose of the Study:
- To investigate ECG patterns, including crochetage, in patients with cryptogenic stroke and PFO.
- To determine if specific ECG findings correlate with the presence of PFO.
Main Methods:
- Prospective enrollment of 104 patients with cryptogenic stroke undergoing right-to-left shunt (RLS) studies.
- ECG analysis by two blinded cardiologists for crochetage, P wave abnormalities, and right bundle branch block (RBBB).
- Correlation of ECG findings with PFO detection via transesophageal echocardiography and transcranial Doppler.
Main Results:
- Patent foramen ovale (PFO) was detected in 40.4% of patients.
- No statistically significant difference in crochetage or RBBB prevalence was found between patients with and without PFO.
- P wave abnormalities were more frequent in patients with PFO, and biphasic P waves were associated with smaller RLS.
Conclusions:
- The study found no characteristic ECG pattern to reliably identify patients with cryptogenic stroke and PFO.
- Current ECG findings do not serve as a definitive marker for PFO in this patient group.
Background:
A characteristic electrocardiogram (ECG) pattern called crochetage has been described in patients with atrial septal defects. Nevertheless, there are discrepancies regarding its frequency in patients with patent foramen ovale (PFO).
Objective:
We analyzed the ECGs of patients who had cryptogenic stroke to study crochetage and other possible patterns in relation to PFO.
Methods:
We prospectively included consecutive patients who have had a cryptogenic stroke and are undergoing a right-to-left shunt (RLS) study with transesophageal echocardiography and simultaneous transcranial Doppler. Two blinded and independent cardiologists analyzed the ECGs for crochetage, defined as a notch near the apex of the R wave in inferior limb leads, P wave abnormalities, and right bundle branch block (RBBB).
Results:
We studied 104 patients whose mean age was 55.1 +/- 12.7 years; 60.6% were men. PFO was detected in 40.4% of patients. Cardiologists recorded crochetage in 26.2% of patients with PFO and 14.5% of patients without PFO (P = .204) and RBBB in 19% and 8% of patients, respectively (P = .132). P wave abnormalities were also detected in 54.8% of patients with PFO and 35.5% of patients without PFO (P = .070). In patients with PFO, biphasic P waves were more frequent in small RLS (P = .006). Although higher frequencies of crochetage in small RLS and RBBB in moderate RLS were detected, these differences did not reach statistical significance (P = .067 and P = .05, respectively).
Conclusion:
There is no characteristic ECG pattern to identify the patients with cryptogenic stroke.
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