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Synovial sarcoma: a clinicopathological study of 36 cases
R Golouh1, V Vuzevski, M Bracko
1Department of Pathology, Institute of Oncology, Ljubljana, Yugoslavia.
Journal of Surgical Oncology
|September 1, 1990
Summary
Synovial sarcoma prognosis is significantly impacted by high mitotic rates and tumor necrosis. Keratin positivity is a sensitive marker for epithelial differentiation in these tumors.
Area of Science:
- Oncology
- Pathology
- Surgical Pathology
Background:
- Synovial sarcoma is a rare soft tissue sarcoma.
- Understanding prognostic factors is crucial for patient management.
Purpose of the Study:
- To conduct a clinicopathologic study of synovial sarcoma.
- To evaluate immunohistochemical markers for epithelial differentiation.
- To identify prognostic factors influencing patient survival.
Main Methods:
- Clinicopathologic analysis of 36 synovial sarcoma cases.
- Inclusion of electron microscopy and immunohistochemistry.
- Evaluation of keratin, epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA) expression.
Main Results:
- Keratin was a sensitive marker for epithelial differentiation (92% biphasic, 57% monophasic).
- Overall 5-year survival was 64%.
- High mitotic rate (>15 per 10 HPF) and necrosis with a mitotic rate >5 per 10 HPF significantly reduced survival.
Conclusions:
- Keratin is a valuable marker in synovial sarcoma diagnosis.
- Tumor necrosis and high mitotic activity are significant negative prognostic indicators.
- Further research may refine prognostic models for synovial sarcoma.