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Updated: Jul 20, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
Published on: February 19, 2019
Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR
Samantha A Roberts1, Gordon G Churchward, June R Scott
1Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Abstract:
The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.
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