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Long-term neurocognitive function after critical illness.

Ramona O Hopkins1, James C Jackson

  • 1Department of Internal Medicine, Critical Care Medicine, LDS Hospital, Eighth Ave and C St, Salt Lake City, UT 84143, USA. Ramona.Hopkins@intermountainmail.org

Chest
|September 12, 2006
PubMed
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Critical illness can cause lasting neurocognitive impairments affecting daily function and quality of life. Further research is needed to understand these long-term cognitive outcomes in intensive care unit survivors.

Area of Science:

  • Critical Care Medicine
  • Neuroscience
  • Neuropsychology

Background:

  • Historically, critical care focused on survival, neglecting long-term patient outcomes.
  • Chronic neurocognitive dysfunction post-critical illness is increasingly recognized but previously underreported.
  • Neurocognitive outcomes have been studied extensively in other patient populations.

Purpose of the Study:

  • To review the current literature on long-term neurocognitive outcomes after critical illness.
  • To highlight the prevalence and impact of cognitive impairment in ICU survivors.

Main Methods:

  • Literature review of studies on long-term neurocognitive outcomes in critically ill patients.

Main Results:

  • Critical illness frequently results in significant neurocognitive impairments that persist for months to years.

Related Experiment Videos

  • These impairments impact quality of life, return to work, functional ability, and incur economic costs.
  • Potential mechanisms include delirium, hypoxia, metabolic issues, inflammation, and sedatives, especially in vulnerable individuals.

    • Conclusions:

    • Neurocognitive sequelae are common, potentially permanent, and impair daily function and quality of life post-critical illness.
    • Inability to return to work is a significant consequence for survivors.
    • Further research is essential to elucidate the prevalence, risk factors, and nature of these neurocognitive impairments.