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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Influence of rapeseed phospholipids on ibuprofen dissolution from solid dispersions.
M Sosada1, M Gorecki, B Pasker
1Department of Drug Technology, Faculty of Pharmacy, Medical University of Silesia, Sosnowiec, Poland. msosada@slam.katowice.p
Die Pharmazie
|September 13, 2006
Summary
Solid dispersions with rapeseed lecithin ethanol soluble fraction (LESF) significantly enhanced ibuprofen (IB) dissolution. Polyethylene glycol 8,000 further improved IB release, suggesting potential for controlled-release formulations.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Improving the dissolution rate of poorly soluble drugs like ibuprofen (IB) is crucial for enhancing bioavailability.
- Solid dispersions are a promising strategy for drug delivery, utilizing carriers to improve drug solubility and dissolution.
- Rapeseed lecithin and its fractions are explored as potential excipients in pharmaceutical formulations.
Purpose of the Study:
- To evaluate the dissolution profiles of ibuprofen (IB) from solid dispersions prepared with rapeseed lecithin ethanol soluble fraction (LESF) and rapeseed phosphatidylcholine (RPC).
- To investigate the impact of polyethylene glycol (PEG) 4,000 and PEG 8,000 incorporation on the controlled-release of IB from these solid dispersions.
- To determine the effect of LESF concentration on IB dissolution enhancement.
Main Methods:
- Solid dispersions of ibuprofen were prepared using the solvent evaporation method.
- Dissolution studies were conducted in double-distilled water using a paddle dissolution apparatus.
- The influence of LESF, RPC, PEG 4,000, and PEG 8,000 on ibuprofen dissolution rates and extent was analyzed.
Main Results:
- Solid dispersions containing LESF exhibited double the initial dissolution rate and maximum dissolved ibuprofen compared to those with RPC (4:1 w/w).
- Increasing LESF concentration from 0% to 20% in solid dispersions resulted in a 60% to 100% improvement in maximum IB dissolution compared to IB alone.
- PEG 4,000 slightly decreased IB dissolution rate, whereas PEG 8,000 significantly enhanced IB dissolution under the tested conditions.
Conclusions:
- Rapeseed lecithin ethanol soluble fraction (LESF) is an effective carrier for enhancing ibuprofen dissolution from solid dispersions.
- Polyethylene glycol 8,000 demonstrates significant potential in improving ibuprofen release profiles from solid dispersions.
- These findings suggest that LESF and PEG 8,000 can be valuable components in developing advanced ibuprofen formulations for controlled release.
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