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Updated: Jul 20, 2026

Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
Published on: August 9, 2024
A practical approach for quantitative estimates of voxel-by-voxel liver perfusion using DCE imaging and a
Yue Cao1, Jonathan Alspaugh, Zhou Shen
1Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Abstract:
Voxel-by-voxel estimation of liver perfusion using nonlinear least-squares fits of dynamic contrast enhanced computed tomography or magnetic resonance imaging data to a compartmental model is a computational expensive process. In this report, a "linear" least-squares method for estimation of liver perfusion is described. Simulated data and the data from an example case of a patient with intrahepatic cancer are presented. Compared to the nonlinear method, the new method can improve computational speed by a factor of approximately 400, which makes it practical for use in clinical trials.
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