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Related Experiment Videos

Worms and allergy.

E M Carvalho1, L S Bastos, M I Araújo

  • 1Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil. edgar@ufba.br

Parasite Immunology
|September 13, 2006
PubMed
Summary
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Helminth infections, particularly chronic ones, can decrease allergies and asthma severity by modulating the immune system. This immune modulation involves down-regulating type 1 and type 2 responses, often through increased IL-10 production.

Area of Science:

  • Immunology
  • Allergy Research
  • Parasitology

Background:

  • Worms and asthma share a type 2 immune response pathway.
  • Helminth infections show a negative association with atopy, allergic disease prevalence, and asthma severity.
  • Allergic responses require appropriate immune modulation, unlike helminth infections where host mechanisms down-regulate the immune response.

Purpose of the Study:

  • To explore the complex relationship between helminth infections and allergic diseases.
  • To understand the immune mechanisms by which helminths modulate allergic responses.
  • To identify factors influencing the interaction between helminths and allergy.

Main Methods:

  • Review of existing evidence on helminth infection and immune responses.

Related Experiment Videos

  • Analysis of immunological mechanisms, including cytokine production and cell populations (T cells, NKT cells).
  • Consideration of variables like infection phase, parasite load, and helminth species.

    • Main Results:

    • Helminth infection leads to decreased type 1 and type 2 immune responses.
    • Increased Interleukin-10 (IL-10) production is a key mechanism for immune down-modulation.
    • Chronic helminth infection is associated with decreased atopy, while acute infection may exacerbate allergies.
    • Parasite load and species (e.g., Schistosoma mansoni) are critical factors in immune modulation.

    Conclusions:

    • Helminths can suppress allergic immune responses through various mechanisms.
    • The phase and intensity of helminth infection significantly influence its effect on allergies.
    • Further research, particularly focusing on specific helminth species like Schistosoma mansoni, is crucial for understanding and potentially harnessing these immunomodulatory effects.