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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

Amphiphilic polyanhydrides for protein stabilization and release.

María P Torres¹, Amy S Determan, Gretchen L Anderson

¹Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.

|September 13, 2006

Summary

Novel biodegradable polyanhydride microspheres stabilize and sustain the release of therapeutic proteins. This CPTEG:CPH system preserves protein structure and biological activity, showing promise for in vivo applications.

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Published on: October 10, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery

Background:

Developing effective delivery systems for therapeutic peptides and proteins is crucial.
Polyanhydrides offer potential as biodegradable carriers due to their tunable properties.

Purpose of the Study:

To design and synthesize novel amphiphilic biodegradable polyanhydride systems.
To evaluate these systems for the stabilization and sustained release of model proteins.

Main Methods:

Synthesized copolymers of 1,6-bis(p-carboxyphenoxy)hexane (CPH) and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG).
Fabricated microspheres using solid/oil/oil double emulsion and cryogenic atomization.
Assessed protein stabilization and structure using gel electrophoresis, circular dichroism, and fluorescence spectroscopy.

Main Results:

The CPTEG:CPH polyanhydride system effectively stabilized model proteins (lysozyme, ovalbumin).
Structural integrity of encapsulated and released proteins was maintained.
Biological activity of the released proteins was preserved.

Conclusions:

Amphiphilic polyanhydride microspheres demonstrate potential for protein stabilization.
The CPTEG:CPH system facilitates sustained release while maintaining protein structure and function.
These findings support further in vivo investigation for therapeutic protein delivery.