Related Experiment Video
Updated: Jul 20, 2026
Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection
Published on: October 3, 2025
Sildenafil reduces postoperative adhesion formation in a rat uterine horn model
Cem Batukan1, Mahmut T Ozgun, Mustafa Basbug
1Erciyes University, School of Medicine, Department of Obstetrics and Gynecology, Gevher Neshibe Hospital, 38039 Kayseri, Turkey. cbatukan@erciyes.edu.tr
Objective:
The purpose of this experimental study was to evaluate the effect of oral sildenafil on postoperative adhesion formation in rats.
Study Design:
Thirty-two Wistar Albino rats were subjected to standardized lesion by cauterization of the uterine horn and abrasion of the adjacent parietal peritoneum. They were randomized to receive sildenafil at a daily dose of 15 mg/kg, 7.5mg/kg and 3.75 mg/kg or placebo. Sildenafil was administered by gavage 1h before the operation and daily for 5 days after the procedure. The extent and severity of adhesions were assessed on the 14th postoperative day.
Result(S):
The severity but not extent of adhesions in rats given 15 mg/kg sildenafil was significantly less when compared with the other groups (<0.001).
Conclusion:
Sildenafil diminishes peritoneal adhesion formation in rat.
