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Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Pharmacogenetics and Pharmacogenomics: Overview01:29

Pharmacogenetics and Pharmacogenomics: Overview

Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...

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Related Experiment Video

Updated: Jul 20, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Epigenetics, disease, and therapeutic interventions.

Q Lu1, X Qiu, N Hu

  • 1Department of Dermatology and Epigenetic Research Center, Second Xiangya Hospital, Central South University, Hunan 410011, PR China.

Ageing Research Reviews
|September 13, 2006
PubMed
Summary

Epigenetic changes, like DNA methylation and histone acetylation, influence gene expression and are linked to age-related diseases. Therapeutic modification of these reversible epigenetic marks offers new treatment strategies.

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Last Updated: Jul 20, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
09:56

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

Published on: October 31, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Epigenetic mechanisms, including DNA methylation and histone modifications (e.g., acetylation), regulate gene expression without altering DNA sequence.
  • DNA hypermethylation and histone hypoacetylation typically silence genes, whereas hypomethylation and histone acetylation promote transcription.
  • Aberrant epigenetic modifications are associated with age-related diseases such as cancer and autoimmune disorders.

Purpose of the Study:

  • To review the role of epigenetic alterations in disease pathogenesis.
  • To discuss recent advancements in therapeutic strategies targeting epigenetic modifications.

Main Methods:

  • Review of existing literature on epigenetics and disease.
  • Analysis of studies investigating therapeutic interventions for epigenetic dysregulation.

Main Results:

  • Epigenetic changes are fundamental to gene expression regulation and disease development.
  • Aberrant epigenetic marks are implicated in various age-related conditions.
  • The reversibility of epigenetic alterations presents opportunities for novel therapeutic approaches.

Conclusions:

  • Epigenetic mechanisms play a critical role in the development of age-related diseases.
  • Targeting and modifying epigenetic marks represent a promising avenue for developing new disease therapies.