Related Experiment Video
Updated: Jul 20, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
Published on: June 18, 2018
Using addiction severity profiles to differentiate cocaine-dependent patients with and without comorbid major
Adam M Leventhal1, Marc E Mooney, Katherine A DeLaune
1Department of Psychology, the University of Houston, Houston, Texas 77204-5022, USA. aleventhal@uh.edu
Abstract:
This study compared pretreatment addiction severity profiles of 339 abusers in three diagnostic groups: cocaine dependence only (CO), cocaine dependence with substance-induced major depression (SIMD), and cocaine dependence with independent major depression (IMD). Depressed subjects reported more severe problems than non-depressed subjects across numerous domains, regardless of diagnostic etiology. These findings support the need for specialized treatment approaches targeting depressive symptoms or life stress for cocaine-dependent patients with IMD or SIMD, though patients with IMD may require additional attention for chronic and comorbid psychiatric and medical problems.
Related Concept Videos
Drug Dependence
Drug Abuse and Addiction: Pharmacological Phenomena
Depressive Disorders: MDD and Dysthymia
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Substance Use Disorders Affecting Sleep
Understanding the concepts of physical dependence,...
Depression: Overview

