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Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: Jul 20, 2026

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Co-culture of Glioblastoma Stem-like Cells on Patterned Neurons to Study Migration and Cellular Interactions

Published on: February 24, 2021

Primary glioblastomas express mesenchymal stem-like properties.

Cho-Lea Tso¹, Peter Shintaku, James Chen

¹Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Room 5506, 695 Young Drive South, Los Angeles, CA 90095, USA.

Molecular Cancer Research : MCR

|September 13, 2006

Summary

Primary glioblastoma tumors exhibit mesenchymal stem cell (MSC) properties, suggesting a potential origin from transformed stem cells. These glioblastoma cells can differentiate into various mesenchymal lineages, impacting tumor growth.

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Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion

Published on: August 29, 2018

Area of Science:

Neuro-oncology
Cancer Stem Cell Biology
Mesenchymal Stem Cell Research

Background:

Glioblastoma is an aggressive primary brain cancer.
Brain tumor-initiating cells suggest transformed neural stem cells may cause glioblastoma.
Mesenchymal transcripts are overexpressed in primary glioblastoma but not secondary tumors or normal brain.

Purpose of the Study:

To investigate mesenchymal stem cell (MSC)-like properties in primary glioblastoma.
To determine if glioblastoma cell cultures can differentiate into mesenchymal lineages.

Main Methods:

Analysis of primary glioblastoma tumors and derived cell lines for MSC markers.
Induction of differentiation in glioblastoma cell cultures into multiple mesenchymal lineages.

Main Results:

A subset of primary glioblastoma tumors and their derived lines express MSC-associated markers.
Glioblastoma cell cultures demonstrated differentiation into various mesenchymal lineage-like cell types.

Conclusions:

Primary glioblastomas may originate from transformed stem cells with MSC-like properties.
Alternatively, glioblastomas may activate genes conferring mesenchymal properties for tumor progression.
These findings offer insights into glioblastoma origins and therapeutic targets.