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A cerebral granular cell tumor in a cat
M T Mandara1, G Ricci, M Sforna
1Department of Biopathological Veterinary Science, School of Veterinary Medicine, Via S. Costanzo n. 4, 06126 Perugia, Italy. mandara@unipg.it
Veterinary Pathology
|September 13, 2006
Summary
A rare cerebral granular cell tumor was found in a cat, infiltrating the third ventricle. Immunohistochemistry suggests a meningeal origin for this feline brain tumor.
Area of Science:
- Veterinary Pathology
- Neuro-oncology
- Comparative Oncology
Background:
- Granular cell tumors (GCTs) are rare neoplasms with diverse origins.
- Cerebral GCTs are exceptionally uncommon in domestic animals.
- Understanding the cell of origin is crucial for diagnosis and prognosis.
Observation:
- A cerebral granular cell tumor was identified in a 6-year-old female cat.
- The tumor was located above the corpus callosum, infiltrating the third ventricle.
- Histopathology showed large cells with intracytoplasmic granules, psammoma body-like patterns, and cholesterinic degeneration.
Findings:
- Immunohistochemistry revealed diffuse, strong vimentin positivity in neoplastic cells.
- Tumor cells were negative for cytokeratins, lysozyme, and synaptophysin.
- Morphological and immunohistochemical features supported a meningeal origin.
Implications:
- This case expands the understanding of cerebral granular cell tumors in felines.
- The findings suggest a potential origin from meningeal elements within the brain.
- Further research can clarify the pathogenesis and diagnostic markers for feline meningeal tumors.
