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05:01
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
Obesity and traumatic brain injury
Carlos V R Brown1, Peter Rhee, Angela L Neville
1Los Angeles County/University of Southern California Medical Center, Department Surgery, Division of Trauma and Critical Care, Los Angeles, California 90033, USA. carlosbr@usc.edu
The Journal of Trauma
|September 13, 2006
Summary
Obese patients with traumatic brain injury (TBI) showed higher mortality and complications, but obesity was not an independent risk factor. These outcomes were linked to age and other injuries, not obesity itself.
Area of Science:
- Trauma Surgery
- Neurosurgery
- Obesity Medicine
Background:
- Rising obesity rates necessitate understanding its impact on patient outcomes.
- Traumatic brain injury (TBI) is a significant cause of morbidity and mortality.
- The specific effects of obesity on TBI patients require further investigation.
Purpose of the Study:
- To compare outcomes of obese versus lean patients following traumatic brain injury (TBI).
- To identify if obesity is an independent risk factor for adverse outcomes in TBI patients.
- To analyze the influence of obesity on mortality, complications, and recovery metrics.
Main Methods:
- Retrospective analysis of blunt trauma patients with TBI admitted to an urban Level I trauma center (1998-2003).
- Patients categorized as lean (BMI <30 kg/m2) or obese (BMI ≥30 kg/m2) based on Body Mass Index (BMI).
- Comparison of demographics, injury characteristics, mortality, complications, ventilation days, and length of stay using univariate and multivariate analyses.
Main Results:
- Obese TBI patients were older, had lower admission systolic blood pressure, and more frequent associated chest injuries.
- A trend towards more complications (34% vs. 28%) and higher mortality (36% vs. 25%) was observed in obese patients.
- Multivariate analysis did not identify obesity as an independent risk factor for morbidity or mortality in TBI patients.
Conclusions:
- Obese patients with TBI experienced higher complication and mortality rates.
- These adverse outcomes in obese TBI patients were attributed to confounding factors like age and associated injuries.
- Obesity itself was not found to be an independent predictor of poor outcomes after traumatic brain injury.
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