Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acidosis impairs the coagulation: A thromboelastographic study.

Martin Engström1, Ulf Schött, Bertil Romner

  • 1Department of Anaesthesia and Intensive Care, Lund University Hospital, Lund, Sweden. martin.engstrom@med.lu.se

The Journal of Trauma
|September 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-evaluating albumin use in traumatic brain injury.

Journal of intensive care·2025
Same author

Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation.

Heliyon·2025
Same author

Vitamin K1 Administration Increases the Level of Circulating Carboxylated Osteocalcin in Critically Ill Patients.

Nutrients·2025
Same author

Impact of direct oral anticoagulants on ROTEM® variables; a sample size-calculated experimental study.

Scandinavian journal of clinical and laboratory investigation·2024
Same author

Synergistic effects of rivaroxaban and hypothermia or acidosis on coagulation initiation measured with ROTEM<sup>®</sup>: a prospective observational study.

Thrombosis journal·2024
Same author

Continuous measurement in neurocritical care of cerebral blood flow (CBF) calculated from ICP and central venous pressure.

Scientific reports·2024

Acidosis significantly impairs blood coagulation, slowing clot formation. This study demonstrates a direct causal link between lower pH levels and reduced clotting ability, impacting patient outcomes.

Area of Science:

  • Biochemistry
  • Hematology
  • Critical Care Medicine

Background:

  • Coagulopathy is a major factor in bleeding patient mortality.
  • Acidosis is linked to poor outcomes in trauma and co-occurs with coagulopathy.
  • The causal role of acidosis in coagulopathy development was previously unstudied.

Purpose of the Study:

  • To investigate if acidosis is a causal factor in the development of coagulopathy.
  • To quantify the impact of varying pH levels on blood coagulation.

Main Methods:

  • Blood samples from healthy volunteers were adjusted to pH levels ranging from 7.4 to 6.8 using hydrochloric acid.
  • Thromboelastography was used to assess coagulation parameters at different pH levels.

Main Results:

Related Experiment Videos

  • A strong correlation was found between decreased pH and impaired coagulation.
  • Clot strength formation slowed significantly below pH 7.4.
  • At pH 6.8, clot formation time increased by 168% compared to pH 7.4 (p < 0.00001, r = 0.89), while clotting initiation remained unaffected.

Conclusions:

  • Acidosis demonstrably causes significant impairment of blood coagulation.
  • The degree of impairment from pH 7.4 to 7.15 is comparable to that caused by a 4°C drop in temperature.