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Related Experiment Video

Updated: Jul 20, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

Published on: October 4, 2024

[Pre-menstrual cyclic mastalgia].

Laurival A De Luca¹, Maria de Fátima V S Gonçalves, Lídia Raquel de Carvalho

¹Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP.

Revista Da Associacao Medica Brasileira (1992)

|September 13, 2006

Summary

This study found that low-dose aspirin and vitamin supplements showed no significant difference compared to placebo in treating cyclic mastalgia pain. Simple symptomatic treatment or placebo may be effective for this physiological condition.

Area of Science:

Gynecology
Pharmacology
Clinical Trials

Context:

Cyclic mastalgia is a common condition often treated with various medications.
The underlying mechanisms are thought to be physiological, suggesting simpler interventions may be effective.

Purpose:

To compare the therapeutic effects of low-dose acetylsalicylic acid (aspirin) and a vitamin compound (retinol, pyridoxine hydrochloride, tocopherol acetate) against a placebo for cyclic mastalgia.

Summary:

A prospective, triple-blinded, randomized controlled trial involving 81 patients with cyclic mastalgia was conducted.
Patients were divided into three groups receiving aspirin, vitamins, or placebo.
Pain intensity decreased in all groups, with a more pronounced reduction observed in the placebo group, though no statistically significant differences were found between treatments.

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Published on: December 23, 2022

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Last Updated: Jul 20, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis

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Published on: October 4, 2024

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Impact:

The findings suggest that symptomatic treatment with simple drugs or placebo may be sufficient for cyclic mastalgia.
This challenges traditional multi-drug therapeutic approaches, highlighting potential benefits of simpler interventions and questioning their contraindications.