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Updated: Jul 20, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
[Aspirin resistance theory]
Aleksandra Porosińska1, Krystyna Pierzchała
1Katedra i Klinika Neurologii, Slaska Akademia Medyczna, ul. 3 Maja 13/15, 41-800 Zabrze. aleksandraporosinska@tlen.pl
Abstract:
Acetylsalicylic acid is an effective antiplatelet drug for primary and secondary prevention of heart and brain vascular diseases. Analyses of trials including patients with atherosclerosis proved that vascular ischaemic events have been reduced by 25% and risk of vascular death has been reduced due to aspirin. The increasing number of reports about aspirin resistance (the failure of the compound to protect from an ischemic event despite regular intake of appropriate doses) is alarming. The purpose of this review is to present current opinions and results of investigations connected with this problem.
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