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Related Concept Videos

Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Nephrotic Syndrome I : Introduction01:24

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Related Experiment Video

Updated: Jul 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

[Systemic lupus erythematodes].

J Lukác1, J Rovenský, O Lukácová

  • 1Národný ústav reumatických chorôb, Piestany, Slovenská republika. lukac@nurch.sk

Vnitrni Lekarstvi
|September 14, 2006
PubMed
Summary

Systemic lupus erythematosus (SLE) is a chronic autoimmune condition where the body attacks itself, leading to widespread inflammation. While survival has improved, managing SLE remains complex, requiring multidisciplinary medical collaboration.

Area of Science:

  • Immunology
  • Rheumatology
  • Genetics

Context:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disorder.
  • Characterized by autoantibody production against various autoantigens.
  • Etiopathogenesis involves genetic, immunologic, hormonal, and environmental factors.

Purpose:

  • To summarize the key aspects of Systemic Lupus Erythematosus (SLE).
  • To highlight the multifaceted nature of SLE's development and presentation.
  • To underscore the challenges in diagnosing and managing SLE.

Summary:

  • SLE involves chronic inflammation due to immunocomplex deposition and cytotoxic damage.
  • It affects multiple organs and systems, presenting with diverse symptoms.
  • Despite improved survival rates, SLE management is intricate and requires interdisciplinary care.

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

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Last Updated: Jul 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Impact:

  • Improved patient survival in recent decades.
  • Highlights the need for collaborative, multidisciplinary approaches in SLE care.
  • Emphasizes the ongoing complexity in SLE diagnosis, monitoring, and treatment.