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Updated: Jul 20, 2026
04:14
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
Published on: April 16, 2019
[Nonalcoholic steatohepatitis--current treatment options]
Krzysztof Gutkowski1, Dorota Gutkowska, Mariusz Partyka
1Oddział Chorób Wewnetrznych z Pododdziałem Intensywnej, Opieki Kardiologicznej Szpitala Ministerstwa Spraw Wewnetrznych i Administracji w Rzeszowie. kgutski@intertele.pl
Przeglad Lekarski
|September 14, 2006
Summary
Nonalcoholic steatohepatitis (NASH) is a liver condition linked to insulin resistance. Current management focuses on risk factors, with new treatments under investigation.
Area of Science:
- Hepatology
- Endocrinology
- Internal Medicine
Context:
- Nonalcoholic steatohepatitis (NASH) presents with liver biopsy findings similar to alcoholic hepatitis but in patients without significant alcohol consumption.
- Insulin resistance is the leading theory for the pathogenesis of NASH, progressing from hepatic steatosis to steatohepatitis.
Purpose:
- To review current knowledge on nonalcoholic steatohepatitis (NASH).
- To focus on existing and emerging therapeutic options for NASH currently in clinical trials.
Summary:
- NASH diagnosis is based on liver biopsy findings in the absence of excessive alcohol intake.
- While evidence-based medicine lacks definitive therapies, risk factor modification (obesity, hyperlipidemia, diabetes control) is recommended.
- Ongoing research explores novel pharmacological agents for NASH treatment, with several in various clinical trial phases.
Impact:
- Provides an overview of NASH pathophysiology and current management strategies.
- Highlights the unmet need for effective NASH therapies.
- Informs clinicians and researchers about the evolving landscape of NASH treatment options.
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