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Sequential radiologic and functional pulmonary changes in patients with paraquat intoxication
Jin Won Huh1, Sang Bum Hong, Chae-Man Lim
1Division of Pulmonary and Critical Care Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 388-1, Pungnap-dong, Songpa-gu, Seoul, Korea.
International Journal of Occupational and Environmental Health
|September 14, 2006
Summary
Paraquat lung damage shows sequential changes on high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). Lung damage from paraquat ingestion is reversible, with gradual improvements observed over six months.
Area of Science:
- Pulmonology
- Toxicology
- Radiology
Background:
- Paraquat ingestion can cause severe lung injury.
- Long-term outcomes of paraquat-induced lung damage require further investigation.
Purpose of the Study:
- To investigate the sequential changes in paraquat-induced pulmonary damage.
- To correlate high-resolution computed tomography (HRCT) findings with pulmonary function tests (PFTs) over time.
Main Methods:
- A cohort of 27 patients with paraquat ingestion was followed.
- High-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) were performed.
- Patients were categorized into normal and abnormal HRCT groups based on initial findings.
Main Results:
- Ground-glass opacity peaked at 7 days post-ingestion.
- Consolidation and pulmonary fibrosis progressed between 2 weeks and 1 month.
- Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and diffusing capacity showed slight improvement at 6.5 months.
Conclusions:
- Paraquat-induced lung damage exhibits a predictable temporal pattern on HRCT.
- Pulmonary function gradually improves over six months post-intoxication.
- Lung changes are functionally and radiologically reversible with treatment.
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