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HFE mutations and risk of coronary heart disease in middle-aged women

D L van der A1, P H M Peeters, D E Grobbee

  • 1University Medical Center Utrecht, the Netherlands.

European Journal of Clinical Investigation
|September 14, 2006
PubMed

Insights

HFE gene mutations, including C282Y and H63D, do not appear to increase the risk of coronary heart disease (CHD) in middle-aged women. This study found no significant association between HFE carriership and CHD development.

Area of Science:

  • Genetics and Cardiovascular Health
  • Human Molecular Genetics
  • Epidemiology of Chronic Diseases

Background:

  • Heterozygosity for HFE gene mutations (C282Y) is linked to cardiovascular risk, but evidence is inconclusive.
  • The association between HFE mutations and coronary heart disease (CHD) risk requires further investigation.
  • This study focuses on middle-aged women to clarify the role of HFE mutations in CHD risk.

Purpose of the Study:

  • To investigate the association between HFE gene mutations (C282Y and H63D) and the risk of coronary heart disease (CHD).
  • To provide further evidence on whether HFE mutation carriers are at increased risk of CHD.
  • To analyze data from a large cohort of Dutch middle-aged women.

Main Methods:

  • A cohort of 15,236 Dutch middle-aged women was studied.
  • HFE genotyping was performed on 211 CHD cases and 1526 controls.
  • Weighted Cox proportional hazards models were used to estimate hazard ratios for C282Y and H63D carriership.

Main Results:

  • Carriers of the C282Y allele showed no increased risk for CHD (HR = 1.25, 95% CI = 0.74-2.09).
  • No association was found between the H63D mutation and CHD risk (HR = 0.73, 95% CI = 0.43-1.24).
  • Results were adjusted for age and other potential confounders.

Conclusions:

  • HFE mutations (C282Y and H63D) do not appear to influence the risk of coronary heart disease.
  • Findings align with existing literature, supported by an included meta-analysis.
  • The study suggests HFE genotype is not a significant risk factor for CHD in this population.
Abstract

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