Tumor angiogenesis formation of vessels de novo at germ cell tumors

Systemic studies of 346 biopsy specimens and 56 necropsy specimens with testicular germ cell tumors established two types of vessel formation: (1) classic (mature) type, representing a proliferation of the vessel system that already exists; and (2) embryonal type, with a real new formation of vessels from giant multinuclear cells. Vessels and vessel convolutes with wide lumina and thin walls are characteristic of the embryonal type. Essential properties of both types of vessel formation are presented, as well as the gradual transformation of giant multinuclear cells. The way that giant cell formations are created is described, along with their role in the tumor angiogenesis.