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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jul 20, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Managing bone complications of solid tumors.

James R Berenson1, Lakshmi Rajdev, Michael Broder

  • 1Institute for Myeloma and Bone Cancer Research, West Hollywood, California, USA. jberenson@imbcr.org

Cancer Biology & Therapy
|September 14, 2006
PubMed
Summary

Bone metastases in breast, lung, and prostate cancer cause significant morbidity. Bisphosphonates are now a preferred treatment, effectively reducing bone resorption and improving patient quality of life.

More Related Videos

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Related Experiment Videos

Last Updated: Jul 20, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Area of Science:

  • Oncology
  • Bone Metabolism
  • Cancer Metastasis

Background:

  • Bone metastases are frequent in breast, lung, and prostate cancers.
  • Skeletal complications include pain, fractures, and hypercalcemia, stemming from disrupted bone metabolism.
  • These complications arise from tumor cell and bone microenvironment interactions.

Purpose of the Study:

  • To review current treatment options for skeletal complications of bone metastases.
  • To highlight the role of bisphosphonates in managing these complications.

Main Methods:

  • Review of traditional therapies (radiation, surgery, chemotherapy).
  • Emphasis on the mechanism and benefits of bisphosphonates.
  • Focus on treatment goals: pain relief and fracture risk reduction.

Main Results:

  • Bisphosphonates reduce bone resorption.
  • Decreases observed in hypercalcemia, new osteolytic lesions, and fractures.
  • Improved pain management and quality of life for patients.

Conclusions:

  • Bisphosphonates represent a significant advancement in managing bone metastases complications.
  • Effective treatment of skeletal-related events improves patient outcomes and quality of life.