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Endoscopic, rapid near-infrared optical tomography
Daqing Piao1, Hao Xie, Weili Zhang
1School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma, USA. daqing.piao@okstate.edu
Optics Letters
|September 14, 2006
Summary
This study demonstrates the first endoscopic near-infrared (NIR) optical tomography system for rapid, in vivo imaging. The technology uses spread-spectral encoding for blood-based contrast imaging, aiding cancer detection in internal organs.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Optical Tomography
Background:
- Near-infrared (NIR) optical tomography offers potential for blood-based contrast imaging.
- Endoscopic applications require miniaturized systems with rapid imaging capabilities.
Purpose of the Study:
- To demonstrate the first endoscopic near-infrared (NIR) optical tomography system.
- To achieve rapid imaging speeds suitable for in vivo applications.
- To establish feasibility for cancer detection in internal organs.
Main Methods:
- Utilized a spread-spectral-encoding technique with a broadband light source.
- Employed linear-to-circular fiber bundling for endoscopic probing.
- Developed a 12 mm probe with eight sources and eight detectors for tomography.
Main Results:
- Achieved endoscopic NIR tomography at an 8 Hz frame rate.
- Demonstrated the system's functionality in phantoms and tissue specimens.
- Validated the rapid sampling speed for parallel acquisition of source-detector pairs.
Conclusions:
- This work presents a novel endoscopic NIR tomography approach.
- The system enables blood-based contrast imaging at the endoscope scale.
- Feasibility studies support future in vivo cancer detection applications.
