Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human eosinophils express transforming growth factor alpha.

D T Wong1, P F Weller, S J Galli

  • 1Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, Massachusetts 02115.

The Journal of Experimental Medicine
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Performance of ChatGPT in French language analysis of multimodal retinal cases.

Journal francais d'ophtalmologie·2024
Same author

Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.

Anaesthesia·2022
Same author

Evidence-based Canadian guidelines for tele-retina screening for diabetic retinopathy: recommendations from the Canadian Retina Research Network (CR2N) Tele-Retina Steering Committee.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2020
Same author

Inhibition of respiration by aureomycin and terramycin.

Antibiotics & chemotherapy (Northfield, Ill.)·2014
Same author

Mycoplasma genitalium: a review.

International journal of STD & AIDS·2014
Same author

Utility of mesenchymal stromal cells for myocardial infarction. Transitioning from bench to bedside.

Minerva cardioangiologica·2013

Human eosinophils can produce transforming growth factor alpha (TGF-alpha), a cytokine influencing cell proliferation. This TGF-alpha production by eosinophils, especially in diseased tissues, may be regulated by the microenvironment.

Area of Science:

  • Cell Biology
  • Immunology
  • Oncology

Background:

  • Transforming growth factor alpha (TGF-alpha) is a cytokine affecting cell proliferation.
  • Eosinophils are immune cells found in tissues near epithelial cells.

Purpose of the Study:

  • To investigate whether human eosinophils express TGF-alpha.
  • To determine if TGF-alpha expression by eosinophils is influenced by the microenvironment.

Main Methods:

  • In situ hybridization to detect TGF-alpha mRNA in tissue-infiltrating eosinophils.
  • Immunohistochemistry to detect TGF-alpha protein in eosinophils.
  • Polymerase chain reaction and Southern blot analysis for transcript confirmation.

Main Results:

Related Experiment Videos

  • The majority of eosinophils in colonic and oral tumors expressed TGF-alpha mRNA.
  • Eosinophils from a patient with hypereosinophilic syndrome showed high levels of TGF-alpha expression.
  • Normal donor eosinophils had minimal TGF-alpha expression, suggesting microenvironmental regulation.

    • Conclusions:

    • Human eosinophils can express TGF-alpha.
    • TGF-alpha production by eosinophils may be regulated by the surrounding microenvironment.
    • Eosinophil-derived TGF-alpha represents a novel mechanism in physiological and pathological responses.