Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR.

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Solid-state interactions are crucial for drug formulation and nanoparticle formation.
• Polyvinylpyrrolidone (PVP) and sodium dodecyl sulfate (SDS) are commonly used excipients in drug delivery systems.

Purpose of the Study:

• To investigate the effect of polyvinylpyrrolidone (PVP) molecular weight on solid-state interactions in probucol/PVP/sodium dodecyl sulfate (SDS) ternary mixtures.
• To understand the formation of probucol nanoparticles within these ternary ground mixtures using solid-state NMR spectroscopy.

Main Methods:

• Preparation of ternary ground mixtures (GM) of probucol with varying molecular weight PVP (K12, K17, K30, K90) and SDS.
• Solid-state characterization using powder X-ray diffraction (PXRD) and solid-state 13C cross-polarization/magic angle spinning (CP/MAS) NMR spectroscopy.
• Observation of nanoparticle formation using high-resolution scanning electron microscopy (SEM).

Main Results:

• Lower molecular weight PVP (K12) exhibited stronger solid-state interactions with probucol and SDS compared to higher molecular weight PVP.
• The use of lower molecular weight PVP resulted in the formation of smaller probucol nanoparticles (15-25 nm).
• SEM confirmed the presence of these nanometer-sized particles in the probucol/PVP K12/SDS mixtures.

Conclusions:

• Solid-state 13C NMR spectroscopy is effective in detecting grinding-induced interactions in drug/excipient ternary systems.
• Simultaneous interactions between probucol-PVP and PVP-SDS are essential for generating nanometer-sized probucol particles.
• PVP molecular weight significantly influences the intermolecular interactions and subsequent nanoparticle formation in probucol ternary mixtures.