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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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Pulse wave velocity in patients with coronary artery disease or type 2 diabetes mellitus

Marcin Cwynar1, Jerzy Gasowski, Barbara Gryglewska

  • 1Department of Internal Medicine and Gerontology, Medical College, Jagiellonian University, Cracow, Poland.

Acta Cardiologica
|September 15, 2006
PubMed

Insights

Coronary artery disease (CAD) increases arterial stiffness, measured by pulse wave velocity (PWV). Type 2 diabetes mellitus (DM) did not independently affect PWV in this study, suggesting CAD is a primary driver of arterial stiffening.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Metabolic Diseases

Background:

  • Arterial stiffness, assessed by pulse wave velocity (PWV), is a marker of cardiovascular risk.
  • The independent effects of coronary artery disease (CAD) and type 2 diabetes mellitus (DM) on arterial stiffness require further elucidation.

Purpose of the Study:

  • To investigate the differentiating impact of CAD and type 2 DM on arterial stiffness using PWV.
  • To assess PWV as a measure of arterial stiffening in patients with and without CAD and DM.

Main Methods:

  • A study involving 101 participants with a mean age of 63.5 years.
  • Assessment of aortic pulse wave velocity (PWV) in individuals with and without coronary artery disease (CAD) and type 2 diabetes mellitus (DM).
  • Statistical analysis adjusted for established co-variables.

Main Results:

  • PWV was significantly higher in participants with CAD compared to those without (P < 0.01).
  • PWV was also significantly higher in participants with DM compared to those without (P < 0.01) before adjustment.
  • After adjustment for co-variables, DM did not significantly affect PWV, while CAD remained associated with higher PWV.

Conclusions:

  • Coronary artery disease (CAD) is independently associated with increased arterial stiffness (higher PWV).
  • Type 2 diabetes mellitus (DM) did not appear to contribute independently to arterial stiffening after accounting for confounders.
  • Elevated PWV in patients with CAD may indicate widespread atherosclerosis, potentially involving coronary arteries.
Abstract

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