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Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...

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Related Experiment Video

Updated: Mar 3, 2026

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

[Progress in leukocytospermia research].

Jing Li¹, Rui-Zhi Liu

¹Laboratory of Cellular Biology, College of Basic Medicine, Jilin University, Changchun, Jilin 130021, China.

Zhonghua Nan Ke Xue = National Journal of Andrology

|September 15, 2006

Summary

This summary is machine-generated.

Leukocytospermia, a common cause of male infertility, involves white blood cells in semen. Increased reactive oxygen species from these cells damage sperm, contributing to infertility. Treatment can improve semen parameters.

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Last Updated: Mar 3, 2026

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

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Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

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Fluorimetric Techniques for the Assessment of Sperm Membranes

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

Area of Science:

Reproductive Biology
Andrology
Immunology

Context:

Leukocytospermia, characterized by elevated white blood cells in semen, is a significant factor in male infertility.
The precise role and origin of leukocytes in semen remain subjects of ongoing scientific debate.
Previous studies suggest potential negative impacts of leukocytospermia on semen quality and outcomes of assisted reproductive technologies like in vitro fertilization (IVF).

Purpose:

To elucidate the controversial aspects of leukocytospermia, including leukocyte distribution, origin, and functional significance in semen.
To highlight the detrimental effects of leukocytospermia on male reproductive health.
To underscore the therapeutic potential of addressing leukocytospermia for improving fertility outcomes.

Summary:

Leukocytospermia is frequently linked to male infertility, with ongoing research into the distribution and function of leukocytes in semen.
A primary concern is the overproduction of reactive oxygen species (ROS) by leukocytes, which can inflict oxidative damage on sperm.
This sperm damage is a key mechanism contributing to reduced male fertility associated with leukocytospermia.

Impact:

Clarifies the detrimental impact of increased reactive oxygen species (ROS) in leukocytospermia on sperm function.
Emphasizes that managing and preventing leukocytospermia can lead to significant improvements in semen parameters.
Provides a foundation for further research into targeted therapies for male infertility stemming from leukocytospermia.