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Related Experiment Videos

Central nervous system function in systemic lupus erythematosus.

K Elkon1, H Weissbach, N Brot

  • 1Hospital for Special Surgery, Cornell University Medical College, New York, NY 10021.

Neurochemical Research
|April 1, 1990
PubMed
Summary

Autoantibodies targeting ribosomal proteins are found in some systemic lupus erythematosus (SLE) patients. These antibodies are highly prevalent in SLE individuals experiencing psychosis, suggesting a potential link.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Neuroscience

Background:

  • Autoantibodies to eukaryotic 60S ribosomal phosphoproteins P0, P1, and P2 are detected in 10-20% of systemic lupus erythematosus (SLE) patients.
  • These autoantibodies are known to inhibit protein synthesis in vitro and in cultured human cells.
  • A common epitope within the carboxyl-terminal 22 amino acids of these proteins is recognized by the autoantibodies.

Purpose of the Study:

  • To investigate the association between anti-ribosomal protein autoantibodies and central nervous system (CNS) disturbances in SLE patients.
  • To determine the prevalence of these autoantibodies in SLE individuals with psychosis.

Main Methods:

  • Sera from SLE patients, particularly those with diagnosed psychosis, were analyzed for the presence of autoantibodies against ribosomal phosphoproteins P0, P1, and P2.

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  • Comparison of autoantibody levels between SLE patients with and without psychosis.

    • Main Results:

    • Autoantibodies to eukaryotic 60S ribosomal phosphoproteins P0, P1, and P2 were measured in SLE patients with central nervous system disturbances.
    • A significant association was found: 90% of SLE patients diagnosed with psychosis tested positive for these autoantibodies.
    • This indicates a strong correlation between anti-ribosomal protein autoantibodies and psychosis in SLE.

    Conclusions:

    • Autoantibodies targeting ribosomal phosphoproteins P0, P1, and P2 are strongly associated with psychosis in patients with systemic lupus erythematosus.
    • The high prevalence of these autoantibodies in SLE patients with psychosis suggests a potential role in the pathogenesis of neuropsychiatric lupus.
    • Further research is warranted to elucidate the mechanism by which these autoantibodies contribute to CNS manifestations in SLE.